You must pay more attention to the negative effects when using antifungal creams to treat fungal. If there are any abnormal symptoms occurring, particularly the conditions are constantly and worsening, you have to ask for your doctor’s suggestion immediately.
Nowadays in the market, there are many multiple antifungal medicines which are applied to treat fungal. But their usages and effects are not exactly the same. For example, miconazole and nystatin are always used for treating infections of yeast for instance candida, however they can not be effective for treating filamentous fungi. Although ketoconazole and clotrimazole are more widely used for treating pathogenic fungi than the above two creams, they still have less effects compared to some new medicines including butenafine, ciclopirox olamine as well as terbinafine.
1. The treatment of ringworm
1) The reason for suffering ringworm
As a kind of fungal skin disease, the symptoms of ringworm generally is red color, itchy papular lesions. It extends around and forms a circle. Usually some special areas such as under the breasts, armpits, buttocks, the waist surroundings, inguinal skin and so on happen disease of ringworm due to the microsporum fungus, epidermophyton as well as trichophyton.
2) The treatment of ringworm
Generally, some traditional medicines are used for treatment of ringworm. For instance, one medicine is anti mycose i.e. the combination of boric acid, salicylic acid and benzoic acid. Another one is solution ASA i.e. sodium salicylate with aspirin. Additionally liquid alcohol BSI i.e. the combination of lod, benzoic acid and salicylic acid is also used for treating ringworm. With the technology developed, nowadays, some new topical drugs are produced and used to treat ringworm. They are econazole, ketoconazole, miconazole and the other derivatives of imidazole.
Particularly, among of the above mentioned medicines, ketoconazole cream is more effective and fast for treating itchy and inflamed skin of fungal infection. On the other hand, this cream doesn’t make the infected skin light sensitive.
2. The treatment of Yeast Infections
1) The reason for yeast infections
Candida as a kind of yeast can cause the infection of the body in many areas such as the skin,penis, vaginal as well as mouth. Commonly candida infections happen on person suffering HIV infection, immune system disease congenitally, parathyroid insufficiency,and even diabetes.
2) The treatment of yeast infections
Generally, topical miconazole cream are applied to treat cutaneous candidiasis, daubing two times every day. But if dystrophy nail has occurred infection of chronic candida, it really has difficulties in treatment. Proceeding the treatment must be on the basis of fundamental causes. It’s very important to keep nails and hands drying, meanwhile daily using in miconazole cream should persist few months.
As a synthetic imidazole dioxolane, ketoconazole has been proved that it’s effective for preventing sterol biosynthesis from forming esterol and changing lipid components of membranes of the fungal cell, meanwhile also effective for sensitive fungi, fungistatic and fungicidal activity. In addition, because pathogenic fungi fibers of candida albicans are able to grow from status of bud to spores. This changes process can be prevented by ketoconazole.
Ketoconazole is applied widely to treat various pathogenic fungi such as cryptococcus neoformans, sporothrix schenckii, partial aspergillus spp, trichophyton mentagrophytes, T.rubrum, blastomyces dermatitidis, histoplasma capsulatum. In addition, microsporum canis, paracoccidioides brasiliensis, coccidioides immitis, epidermophyton floccosum, candida spp as well as malassezia furfur also can be treated by ketoconazole. Moreover, this cream also has effect on treatment of partial gram-positive bacteria.
3. The treatment of jock itch
1) The reason for jock itch
As a kind of infection of fungal skin, Jock itch which is also named tinea cruris generally happens on the anus initially, and then extends to genitals, buttocks as well as inner thighs. It commonly presents pus is in the middle of the red and stretching speckle. It is cause of very high humidity, particularly it happens on athletes.
2) The treatment of jock itch
Therefore if having jock itch, adopting the treatments methods of controlling moist and together with antifunganl agents will be more effective. If the area of slippery ulcer has superinfection of bacteria, then using antibiotics at the same time. Except that the above mentioned, these topical antifungal agents also are effective for seborrheic dermatitis. Despite that it is unknown about the disease mechanism, the symptoms of scaly and inflammation are obviously reduced if using ciclopirox olamine, ketoconazole and other topical antifungal medicines.
4. The treatment of diaper rash for babies
1) The reason for diaper rash
Commonly if the anal area is under the conditions of wet, moist and urine or diapers used for a long period and can not be changed timely, it’s very easy to occur diaper rash. That is to say if the dirty and unchanged diapers are contacting with baby’s skin for a long time, red and rash on the skin can happen. Further in this case the skin can not be treated in time, pustular and shiny skin will accordingly appear.
In addition, the same symptoms of rash can also happen to acute diarrhea. Generally anus skin becomes red and bright, the stool is watery and bleeding, and then pus ulcers further appears, which can occur on the second 2 day to fifth day after having the acute diarrhea. Furthermore, the skin of baby is very thin which is unable to prevent substances of inflammation, and it’s easy to be invaded than the skin of elder child. On the other hand, the stool ph level in babies using bottle to feed is commonly higher than the infant with breast feeding, meanwhile they are more easier to have skin rash.
2) The treatment of diaper rash
If you want to treat infections of fungi, you can find antifungal cream OTC specially for the babies. Usually some types are used for treatment such as ketoconazole, clotrimazole, miconazole as well as nystatin.
The tips for using antifungal creams
A lot of topical medicines in the market nowadays are consist of an antifungal, an antibiotic and a corticosteroid as its main ingredients. Generally in clinical practice it’s suggested to use these medicines at minimum dose. As a matter of fact that under some conditions, the ingredients of these medicines also can happen interference between them. For instance, the effects of antifungal medicines will be decreased and worsened if the fungal preparations contains steroids.
Cautions for using antifungal creams
1. Wash the area of infection firstly, and keep the area drying. Daub cream a thin layer, and then massage the daubing cream so that make it fully absorbed.
2. the dose of antifungal creams is used 2 times every day, commonly one time in the morning and one time in the evening. The time of treatment is decided by the situations of disease, generally needs one to four weeks even few months.
3. If there is no re-infection after two weeks, the clinical symptoms usually are easy to be cured . Ensure the time of treatment must be enough. However two weeks later if the symptoms are still not improved, you should ask for your doctor to diagnose the disease again. In order to stop the recurrence of yeast infections, you need have a good hygiene and obey the measures of prevention.
4. Notice that the eyes do not contact the medicines. When treating sebaceous dermatitis, the medicines containing corticosteroid can not be combined to use together.
What are the negative effects of antifungal creams
Generally speaking, slow development and difficulties in absorbing are the obvious characteristics of the infections of fungi. For these reasons, it is very hard to treat fungal disease and meanwhile it needs take long time. So, the antifungal medicines need be used for a long time constantly. It’s very important to note the negative effects of antifungal medicines when treating fungi.
For instance, some untoward effects of ketoconazole will happen such as male breast infection, adrenal insufficiency, gastrointestinal bleeding, diarrhea, flatulence, constipation, vomit as well as nausea. In addition, you may feel drowsiness or agitation, dizziness and headache. Even liver enzymes is increased, the skin occurs rash, urticaria, dermatitis and so on. The appearance of above negative effects are connected with the uses of dose, so the negative influence can be reduced to minimum by controlling the doses.
It has reported that some patients suffering onychomycosis and chronic extending fungal skin has got toxic liver during the treatment. Ketoconazole lead to the effects of toxicity towards liver, despite that its toxicity can be reversed after medicines discontinuation in several months, there are still several cases such as liver fatty change, fulminant hepatic necrosis as well as be fatal.
When using antifungal drugs, ketoconazole has very high toxicity towards liver. Particularly also using the other medicines at the same time, which can lead to the liver toxicity. Therefore it needs take care to monitor medicines effects, special in those patients who require a treatment for long time, or with a historical liver disease. Under such conditions, you’re suggested to use local ketoconazole medicine.
Ketoconazole is able to effectively inhibit hepatic enzymes, the second generation H1-antihistamines, anti-cancer medicines, tranquilizers, steroids and also increase the anticoagulant’s plasma concentrations. On the other hand, antifungal ketoconazole effects can be decreased by isoniazid, antacids as well as H2 antihistamines.
There are many forms of ketoconazole dosage including oral suspension, shampoos, creams as well as pill. It should be noticed that you should not use the different dosage forms at the same time when they have the same active ingredients.